TODAY’S PATENT – RAS INHIBITORY PEPTIDES AND USES THEREOF

Today’s patent was invented by Timothy Gregory L. Verdine and John Hanney McGee on January 14, 2020, bearing patent no. US10533039.

The present invention provides peptides comprising a sequence of X₋₆X₋₅X₋₄X₋₃X₋₂X₋₁X₁PX₃X₄PX₆X₇PGX₁₀X₁₁AX₁₃X₁₄X₁₅X₁₆LX₁₈X₁₉X₂₀X₂₁X₂₂X₂₃LX₂₅X₂₆ YLX₂₉X₃₀X₃₁X₃₂ (SEQ ID NO: 13) wherein the amino acids X₋₆, X₋₅, X₋₄, X₋₃, X₋₂, X₋₁, X₁, X₃, X₄, X₆, X₇, X₁₀, X₁₁, X₁₃, X₁₄, X₁₅, X₁₆, X₁₈, X₁₉, X₂₀, X₂₁, X₂₂, X₂₅, X₂₆, X₂₉, X₃₀, X₃₁, and X₃₂ are as defined herein. The present invention further provides pharmaceutical compositions comprising the peptides and methods of using the peptides for treating proliferative diseases such as cancer which are associated with Ras. Also provided are methods of screening a library of peptide dimers using a peptide dimer display technology.