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TODAY’S PATENT – PHOSPHORYLATED PLASMINOGEN ACTIVATORS

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TODAY’S PATENT – PHOSPHORYLATED PLASMINOGEN ACTIVATORS

This invention “Phosphorylated plasminogen activators” was invented by Francesco Blasi, Maria Patrizia Stoppelli, Maria Rosaria Mastronicola, Karen Gjersing Welinder, and Isabel Correas was granted a patent on 5th April 1995 by EUIPO bearing patent grant number EP0422198B1 to the patentee. The present invention relates to phosphorylated pro-u-PA and u-PA, their preparation and pharmaceutical compositions containing them and, use of phosphorylated pro-u-PA and u-PA for thrombolytic therapy.

Phosphorylated plasminogen activator, such as phosphorylated prourokinase (pro-u-PA), which is substantially free from unphosphorylated plasminogen activator, may be obtained by phosphorylating unphosphorylated plasminogen activator with a phosporylating enzyme or by separating phosphorylated plasminogen activator from a mixture of phosphorylated plasminogen activator and unphosphorylated plasminogen activator. Phosphorylated pro-u-PA, which is substantially free from unphosphorylated pro-u-PA, is converted by plasmin into phosphorylated u-PA. The phosphorylated plasminogen activators such as phosphorylated pro-u-PA, u-PA and t-PA are useful as thrombolytic agents.

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