HIV-1 Env Fusion Peptide Nanoparticle Carrier Conjugates and their Use

The said invention (US12053519B2) was invented by Peter KwongLi Ou, John Mascola, Baoshan Zhang, Kai Xu, Wing-pui Kong, Yaroslav Tsybovsky, Cara W. Chao, Jeffrey Boyington, Yiran WANG on 23^rd September 2018. Currently; it stands assigned to US Department of Health and Human Services

This disclosure introduces immunogenic conjugates featuring HIV-1 Env fusion peptides linked to a self-assembling protein nanoparticle carrier. These conjugates consist of fusion proteins that form a nanoparticle carrier, with the Env peptides corresponding to specific sequences from the HIV-1 Env protein. The goal is to stimulate a neutralizing antibody response to prevent or treat HIV-1 infections.

Additionally, immunogenic compositions containing these conjugates are described, suitable for pharmaceutical use and potentially including an adjuvant. Methods for generating an immune response and treating or preventing HIV-1 infections are also outlined, involving the administration of the conjugate to at-risk or infected subjects, particularly through a prime-boost immunization protocol.